Improving Lives Through Biomedical Innovation

Paragon Biosciences is an incubator and investor that builds and grows leading biotechnology companies. We help people live longer, healthier lives.


Our Focus

At Paragon Biosciences our philosophy is simple: start with what the patient needs, understand the science behind the disease and then build companies completely focused on addressing unmet needs. That is what drives our successful model of rational drug development which helps speed the approval of important medicines. More than 6,000 diseases today that do not have a treatment available. We will make that number smaller, and help patients live longer, better lives.

Problems people have deemed unsolvable are the problems we are solving.

Our Companies

We develop companies with disciplined, targeted strategies that address specific clinical areas. 


Castle Creek

Castle Creek Pharma employs a unique strategy in selective asset identification and capital efficient development that is driving the company to become one of the industry’s most prolific developers of innovative and high potential late stage therapies for rare genetic dermatology conditions. For more information, please visit


Harmony Biosciences

Harmony Biosciences is an innovative biopharmaceutical company dedicated to identifying, developing, and commercializing novel treatment options for patients with rare diseases. With an emphasis on therapies for sleep and cognitive disorders, Harmony’s goal is to push the boundaries of what science can do to improve the lives of patients.  For more information, please visit

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Skyline Biosciences

Skyline Biosciences is developing first in-kind oncology therapies to treat premalignant and malignant conditions with unmet medical need. Skyline’s mission is to alleviate potentially life-threatening conditions and to improve the quality of life for the patients it serves.  

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Emalex Biosciences

Emalex is committed to developing effective treatments for the Central Nervous System (CNS). Emalex’s focus is on making lives easier for the courageous people living with CNS disorders.



Decade Pharmaceuticals

Decade is a research and development company focused on novel Alzheimer’s disease therapeutics that will fundamentally improve patient outcomes and quality of life.




Developing the latest therapies for those living with serious immunology conditions.


Pipelines of Paragon Companies

We have a diverse pipeline of investigational drugs in four therapeutic areas being tested in clinical trials across our family of companies. 


Our Process

We pride ourselves on creating opportunities where other companies do not. We embrace and overcome challenges to deliver important medicines for patients in need.


Our Responsibility

We believe it is our responsibility to contribute to organizations which improve the human experience, both globally and locally.


Latest News


Jan 3, 2018

Castle Creek Pharmaceuticals to Participate in 5th Annual Dermatology Summit

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Oct 27, 2017

Castle Creek Pharmaceuticals Receives Partners in Progress Award from debra of America

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Oct 5, 2017

Harmony Biosciences Acquires US Rights To Pitolisant From Bioprojet; Raises $270 Million In Equity Financing

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